Maybridge Chemical / Thermo-Fisher, Hit-Finder collection.
The Maybridge Hit-Finder is a 14,400 Compound Cluster based library,
selected using a two-stage process of filtering from the entire
Maybridge heterocyclic compound collection.
First stage filtering was done based on
Lipinski's rule of five
producing about 200,000 compounds.
From this set, a Pharmacophore Fingerprinting process was used and a
cluster analysis was done.
The central compound from each cluster and all singleton compounds
were selected to the Hit-Finder Set.
This selection process gives a selection of drug-like
compounds that, once a hit is found, have on average 10 more closely
related compounds that may be screened for follow up work prior to any
synthetic work being required.
The CGSC currently has a copy of the Hit-Finder Set in both 96 and
384-well format, Our stock is at 100 µm
concentration, which will typicaly give 1 µm assay concentration.
Stocks also exist at 10 mm and 1 mm in 96-well format.
Information on the compounds is available locally through our chemical inventory server
as well as through the Maybridge site.