Maybridge Chemical / Thermo-Fisher, Hit-Finder collection.

The Maybridge Hit-Finder is a 14,400 Compound Cluster based library, Selected using a two stage process of filtering from the entire Maybridge hetocyclic compound collection.
First Stage filtering was done based on Lipinski's rule of five, Producing about 200,000 compounds. From this set a Pharmacphor Fingerprinting process was used and a cluster analysis was done. The central compound from each cluster, and all singleton compounds were selected to for the Hit-finder Set. This selection process gives a selection of Drug like compounds that, once a hit is found, have on average 10 more closely related compounds that may be screened for follow up work prior to any synthetic work being required.

The CGSC currentaly has a copy of the Hit-Finder Set in both 96 and 384 well format, Our stock is at 100µm concentration, which will typicaly give 1µm assay concentration.
Stocks also exist at 10mm and 1mm in 96 well format.

Information on the compounds is available localay through our Chemical inventory server as well as through the Maybridge site http://www.maybridge.com